Culture is regarded as the bloodline of the nation and the spiritual home of its people. Excellentregional culture is the treasure of the Chinese nation. Therefore, it is of extremely important theoretical and practicalsignificance to integrate it into the ideological and political education of college students. Insisting on cultivatingstudents with cultural education is an essential measure to strengthen the ideological and political education work ofcolleges and universities. Through a survey of 1,075 students in 7 colleges and universities in Wenzhou, with statisticalmethods used to conduct multivariate linear regression analysis, it was found that the situation of college students inWenzhou, the publicity of the school, and the experience of culture were the main factors affecting the integrationof Wenzhou’s excellent regional culture into the ideological and political education of college students. We shouldencourage college students should be encouraged to strengthen their self-education, enhance educational guidance,expand educational forms, and optimize the educational environment so as to promote the integration of excellentregional culture into the ideological and political education of college students.